Keio ChemBio Midori Lab. 慶應義塾大学理工学部生命情報学科 荒井研究室

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査読論文

  1. Ujie, Y.; Saito, S.; Fukaya, K.; Urabe, D.; Yaguchi, T.; Arai, M. A. “Aspergillus terreus IFM 65899-THP-1 cells interaction triggers production of the natural product butyrolactone Ia, an immune suppressive compound” Sci. Rep. 2024, 14, 28278. DOI: 10.1038/s41598-024-79837-7.
  2. Asano, Y.; Saito, S.; Ujie, Y.; Iwata, C.; Yaguchi, T.; Arai, M. A. “Activation of secondary metabolism and protease activity mechanisms in the black koji mold Aspergillus luchuensis through co-culture with animal cells” ACS Omega 2024, 9, 43129−43137. DOI: 10.1021/acsomega.4c07124.
  3. Saito, S.*; Arai, M. A.* “Methodology for awakening the potential secondary metabolic capacity in actinomycetes” Beilstein J. Org. Chem. 2024, 20, 753-766 (Review). DOI: 10.3762/bjoc.20.69.
  4. Saito, S.*; Banno, T.; Arai, M. A.* “3-Hydroxy-3-(2-oxopropyl)indolin-2-one, a product of a human-derived Enterocloster strain, is an inhibitor of nitric oxide production” Biosci. Biotechnol. Biochem. 2024, 88, 316-321. DOI: 10.1093/bbb/zbad172.
  5. Suzuki, S.; Saito, S.; Narushima, Y.;  Kodani, S.;  Kagaya, N.; Suenaga, H.; Shin-ya, K.; Arai, M. A. “Notch activator cyclopiazonic acid induces apoptosis in HL-60 cells through calcineurin activation” J. Antibiot. 2024, 77, 30-38. DOI: 10.1038/s41429-023-00673-4 (selected as the highlighted article).
  6. Arai, M. A.*; Makita, Y.; Saito, S.; Suzuki, S.; Narushima, Y.; Izawa, N.; Tanaka, Y.; Furui, K.; Ohue, M.; Ishibashi, M. “The Indole Rocaglamide Induces S and G2/M Phase Cell Cycle Arrest in Small Cell Lung Cancer Cells Through ASCL1 Translation Inhibition” SSRN preprint, 2023. DOI: 10.2139/ssrn.4493242
  7. Saito, S.; Funayama, K.; Kato, W.; Okuda, M.; Kawamoto, M.; Matsubara, T.; Sato, T.; Sato, A.; Otsuguro, S.; Sasaki, M.; Orba, Y.; Sawa, H.; Maenaka, K.; Shindo, K.; Imoto, M.; Arai, M. A. “Dihydromaniwamycin E, a heat-shock metabolite from thermotolerant Streptomyces sp. JA74, exhibits antiviral activity against influenza and SARS-CoV-2 viruses” J. Nat. Prod. 2022, 85, 2583-2591. DOI: 10.1021/acs.jnatprod.2c00550 (selected as the Front cover)
  8. Saito, S.*; Suzuki, S.; Arai, M. A.* “Noaoxazole, a new heat shock metabolite produced by thermotolerant Streptomyces sp. HR41″ J. Antibiot. 2022, 75, 509-513. DOI: 10.1038/s41429-022-00551-5
  9. Hara, Y.; Watanabe, K.; Takaya, A.; Ebihara, I.; Manome, T.; Arai, M. A.; Yaguchi, T.; Ishibashi, M. “Two bioactive compounds, uniformides A and B, isolated from a culture of Nocardia uniformis IFM0856T in the presence of animal cells” Org. Lett. 2022, 24, 4998-5002; correction, Org. Lett. 2022, 24, 5867. DOI:10.1021/acs.orglett.2c02441; DOI:10.1021/acs.orglett.2c02092
  10. Makita, Y.; Saito, S.; Tsuchiya, A.; Ishibashi, M.; Arai, M. A.* “Identification of 1β,2α-epoxytagitinin C as a Notch inhibitor, oxidative stress mechanism and its anti-leukemia activity” J. Nat. Med. 2022, 76, 234-243. DOI: 10.1007/s11418-021-01584-0
  11. Hara, Y.; Tanimura, D.; Manome, T.; Arai, M. A.; Yaguchi, T.; Ishibashi, M. “Isolation of peptidolipin NA derivatives from the culture of Nocardia arthritidis IFM10035T in the presence of mouse macrophage cells”, Heterocycles 2022, 104, 185-190. DOI:10.3987/COM-21-14567
  12. Saito, S.; Xiaohanyao, Y.; Zhou, T.; Nakajima-Shimada, J.; Tashiro, E.; Triningsih, D. W.; Harunari, E.; Oku, N.; Igarashi, Y. “Phytohabitols A-C, δ-Lactone-Terminated Polyketides from an Actinomycete of the Genus Phytohabitans” J. Nat. Prod. 2022, 85, 1697-1703. DOI: 10.1021/acs.jnatprod.2c00137
  13. Saito, S.; Oku, N.; Igarashi, Y. “Mycetoindole, an N-acyl dehydrotryptophan with plant growth inhibitory activity from an actinomycete of the genus Actinomycetospora“ J. Antibiot. 2022, 75, 44-47. DOI: 10.1038/s41429-021-00474-7
  14. Arai, M. A.*; Sakuraba, K.; Makita, Y.; Hara, Y. Ishibashi, M.* “Evaluation of Naturally Occurring HIF-1 Inhibitors for Pulmonary Arterial Hypertension” ChemBioChem. 2021,22,2799-2804. DOI: 10.1002/cbic.202100223
  15. Arai, M. A.*; Ebihara, I.; Makita, Y.; Hara, Y.; Yaguchi, T.; Ishibashi, M. “Isolation of Nocobactin NAs as Notch Signal Inhibitors from Nocardia farcinica, a possibility of invasive evolution” J. Antibiot. 2021, 74, 255-259. DOI: 10.1038/s41429-020-00393-z
  16. Kondo, M.; Matsuyama, N.; Aye, T. Z.; Mattan, I.; Sato, T.; Makita, Y.; Ishibashi, M.; Arai, M. A.; Takizawa, S.; Sasai, H. “Practical Stereoselective Synthesis of C3-Spirooxindole- and C2-Spiropseudoindoxyl-Pyrrolidines via Organocatalyzed Pictet-Spengler Reaction/Oxidative Rearrangement Sequence” Adv. Synth. Catal. 2021, 363, 1-17. DOI: 10.1002/adsc.202001472
  17. Hara, Y.; Totsugi, Y.; Ichikawa, H.; Harada, S.; Fujii, K.; Ahmed, F.; Sadhu, S. K.; Arai, M. A.; Ishibashi, M. “Acacienone, a terpenoid-like natural product having an unprecedented C20 framework isolated from Acacia mangium leaves” J. Nat. Med. 2021, 75, 99-104. DOI:10.1007/s11418-020-01457-y
  18. 荒井緑*，石橋正己，“標的タンパク質指向型天然物単離による天然物ケミカルバイオロジー” 有機合成化学協会誌2021, 79, 684-693. DOI: 10.5059/yukigoseikyokaishi.79.684
  19. Arai, M. A., “Target Protein-Oriented Isolations for Bioactive Natural Products” Chem. Pharm. Bull. 2021, 69, 503-515. DOI: 10.1248/cpb.c21-00040 (Review)
  20. Imoto, M.; Fujimaki, T.; Saito, S.; Tashiro, E. “Androgen receptor antagonists produced by Streptomyces overcome resistance to enzalutamide” J. Antibiot. 2021, 74, 706-716. DOI: 10.1038/s41429-021-00453-y (Review)
  21. Zhang, Z.; Zhou, T.; Yang, T.; Fukaya, K.; Harunari, E.; Saito, S.; Yamada, K.; Imada, C.; Urabe, D.; Igarashi, Y. “Nomimicins B–D, new tetronate-class polyketides from a marine-derived actinomycete of the genus Actinomadura” Beilstein J. Org. Chem. 2021, 17, 2194-2202. DOI: 10.3762/bjoc.17.141
  22. Saito, S.; Indo, K.; Oku, N.; Komaki, H.; Kawasaki, M.; Igarashi, Y. “Unsaturated fatty acids and a prenylated tryptophan derivative from a rare actinomycete of the genus Couchioplanes” Beilstein J. Org. Chem. 2021, 17, 2939-2949. DOI: 10.3762/bjoc.17.203
  23. Arai, M. A.*; Makita, Y.; Yamaguchi, Y.; Kawano, H.; Suganami, A.; Tamura, Y.; Ishibashi, M.* “Total synthesis of lindbladione, a Hes1 dimerization inhibitor and neural stem cell activator isolated from Lindbladia tubulina” Sci. Rep. 2020, 10, 21433. DOI:10.1038/s41598-020-78524-7
  24. Tsuchiya, A.; Makita, Y.; Koyano, T.; Kowithayakorn, T.; Ishibashi, M.*; Arai, M. A.* “Isolation and evaluation of cardenolides from Lansium domesticum as Notch inhibitors” J. Nat. Med. 2020, 74, 758-766. DOI:10.1007/s11418-020-01432-7
  25. Arai, M. A.*; Morita, K.; Kawano, H.; Makita, Y.; Hashimoto, M.; Suganami, A.; Tamura, T.; Sadhu, S. K.; Firoj, A.; Ishibashi, M.* “Target protein-oriented isolation of Hes1 dimer inhibitors using protein based methods” Sci. Rep. 2020, 10, 1381. DOI:10.1038/s41598-020-58451-3
  26. Sato, T.; Arai, M. A.; Yixizhuoma; Hara, Y.; Koyano, T.; Kowithayakorn, T.; Ishibashi, M. “Cadinane sesquiterpenoids isolated from Santalum album using a screening program for Wnt signal inhibitory activity” J. Nat. Med. 2020, 74, 476-481 DOI:10.1007/s11418-019-01380-x
  27. Kobayashi, N.; Hara, Y.; Arai, M. A.; Hara, S.; Gonoi, T.; Yaguchi, T.; Ishibashi, M. “Isolation of inohanalactone, a γ-butyrolactone, from Nocardia inohanensis IFM0092T” Heterocycles 2020, 101, 312-317. DOI:10.3987/COM-19-S(F)11
  28. Saito, S.; Kato, W.; Ikeda, H.; Katsuyama, Y.; Ohnishi, Y.; Imoto, M. “Discovery of “heat shock metabolites” produced by thermotolerant actinomycetes in high-temperature culture” J. Antibiot. 2020, 73, 203-210. DOI:10.1038/s41429-020-0279-4
  29. Saito, S.; Atsumi, K.; Zhou, T.; Fukaya, K.; Urabe, D.; Oku, N.; Karim, M. R. U.; Komaki, H.; Igarashi, Y. “A cyclopeptide and three oligomycin-class polyketides produced by an underexplored actinomycete of the genus Pseudosporangium” Beilstein J. Org Chem. 2020, 16, 1100-1110. DOI:10.3762/bjoc.16.97
  30. Nag, A.; Ali, M. A.; Kawaguchi, H.; Saito, S.; Kawasaki, Y.; Miyazaki, S.; Kawamoto, H.; Adi, D. T. N.; Yoshihara, K.; Masuo, S.; Katsuyama, Y.; Kondo, A.; Ogino, C.; Takaya, N.; Kaneko, T.; Ohnishi, Y. “Ultrahigh Thermoresistant Lightweight Bioplastics Developed from Fermentation Products of Cellulosic Feedstock” Adv. Sustainable. Syst. 2020, 2000193. DOI:10.1002/adsu.202000193

2019年以前の論文

2019年以前の論文一覧につきましては、こちらのPDFファイルよりご覧ください。

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