Keio ChemBio Midori Lab. 慶應義塾大学理工学部生命情報学科 荒井研究室

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2021年の論文

  1. Makita, Y.; Saito, S.; Tsuchiya, A.; Ishibashi, M.; Arai, M. A.* Identification of 1β,2α-epoxytagitinin C as a Notch inhibitor, oxidative stress mechanism and its anti-leukemia activityJ. Nat. Med. in press.
  2. Arai, M. A.*; Sakuraba, K.; Makita, Y.; Hara, Y. Ishibashi, M.* Evaluation of Naturally Occurring HIF-1 Inhibitors for Pulmonary Arterial HypertensionChemBioChem. 2021,22,2799-2804. DOI: 10.1002/cbic.202100223
  3. Arai, M. A.*; Ebihara, I.; Makita, Y.; Hara, Y.; Yaguchi, T.; Ishibashi, M. “Isolation of Nocobactin NAs as Notch Signal Inhibitors from Nocardia farcinica, a possibility of invasive evolution” J. Antibiot. 2021, 74, 255-259. DOI: 10.1038/s41429-020-00393-z
  4. Kondo, M.; Matsuyama, N.; Aye, T. Z.; Mattan, I.; Sato, T.; Makita, Y.; Ishibashi, M.; Arai, M. A.; Takizawa, S.; Sasai, H. “Practical Stereoselective Synthesis of C3-Spirooxindole- and C2-Spiropseudoindoxyl-Pyrrolidines via Organocatalyzed Pictet-Spengler Reaction/Oxidative Rearrangement Sequence” Adv. Synth. Catal. 2021, 363, 1-17. DOI: 10.1002/adsc.202001472
  5. Hara, Y.; Totsugi, Y.; Ichikawa, H.; Harada, S.; Fujii, K.; Ahmed, F.; Sadhu, S. K.; Arai, M. A.; Ishibashi, M. “Acacienone, a terpenoid-like natural product having an unprecedented C20 framework isolated from Acacia mangium leavesJ. Nat. Med. 2021, 75, 99-104. DOI:10.1007/s11418-020-01457-y
  6. Hara, Y.; Tanimura, D.; Manome, T.; Arai, M. A.; Yaguchi, T.; Ishibashi, M. “Isolation of peptidolipin NA derivatives from the culture of Nocardia arthritidis IFM10035T in the presence of mouse macrophage cells”, Heterocycles in press. DOI:10.3987/COM-21-14567
  7. 荒井緑*,石橋正己,“標的タンパク質指向型天然物単離による天然物ケミカルバイオロジー” 有機合成化学協会誌2021, 79, 684-693.
  8. Arai, M. A., “Target Protein-Oriented Isolations for Bioactive Natural Products” Chem. Pharm. Bull. 2021, 69, 503-515 (Review).
  9. Imoto, M.; Fujimaki, T.; Saito, S.; Tashiro, E. Androgen receptor antagonists produced by Streptomyces overcome resistance to enzalutamideJ. Antibiot. in press. DOI: 10.1038/s41429-021-00453-y. (Review)
  10. Saito, S.; Oku, N.; Igarashi, Y. Mycetoindole, an N-acyl dehydrotryptophan with plant growth inhibitory activity from an actinomycete of the genus Actinomycetospora J. Antibiot. in press.
  11. Zhang, Z.; Zhou, T.; Yang, T.; Fukaya, K.; Harunari, E.; Saito, S.; Yamada, K.; Imada, C.; Urabe, D.; Igarashi, Y. Nomimicins B–D, new tetronate-class polyketides from a marine-derived actinomycete of the genus ActinomaduraBeilstein J. Org. Chem. 2021, 17, 2194-2202. DOI: 10.3762/bjoc.17.141

2020年の論文

  1. Arai, M. A.*; Makita, Y.; Yamaguchi, Y.; Kawano, H.; Suganami, A.; Tamura, Y.; Ishibashi, M.* “Total synthesis of lindbladione, a Hes1 dimerization inhibitor and neural stem cell activator isolated from Lindbladia tubulinaSci. Rep. 202010, 21433. DOI:10.1038/s41598-020-78524-7
  2. Tsuchiya, A.; Makita, Y.; Koyano, T.; Kowithayakorn, T.; Ishibashi, M.*; Arai, M. A.* “Isolation and evaluation of cardenolides from Lansium domesticum as Notch inhibitors” J. Nat. Med. 2020, 74, 758-766. DOI:10.1007/s11418-020-01432-7
  3. Arai, M. A.*; Morita, K.; Kawano, H.; Makita, Y.; Hashimoto, M.; Suganami, A.; Tamura, T.; Sadhu, S. K.; Firoj, A.; Ishibashi, M.* “Target protein-oriented isolation of Hes1 dimer inhibitors using protein based methods” Sci. Rep. 2020, 10, 1381. DOI:10.1038/s41598-020-58451-3
  4. Sato, T.; Arai, M. A.; Yixizhuoma; Hara, Y.; Koyano, T.; Kowithayakorn, T.; Ishibashi, M. “Cadinane sesquiterpenoids isolated from Santalum album using a screening program for Wnt signal inhibitory activity” J. Nat. Med. 2020, 74, 476-481 DOI:10.1007/s11418-019-01380-x
  5. Kobayashi, N.; Hara, Y.; Arai, M. A.; Hara, S.; Gonoi, T.; Yaguchi, T.; Ishibashi, M. “Isolation of inohanalactone, a γ-butyrolactone, from Nocardia inohanensis IFM0092T” Heterocycles 2020, 101, 312-317. DOI:10.3987/COM-19-S(F)11
  6. Saito, S.; Kato, W.; Ikeda, H.; Katsuyama, Y.; Ohnishi, Y.; Imoto, M. “Discovery of “heat shock metabolites” produced by thermotolerant actinomycetes in high-temperature culture” J. Antibiot. 2020, 73, 203-210. DOI:10.1038/s41429-020-0279-4
  7. Saito, S.; Atsumi, K.; Zhou, T.; Fukaya, K.; Urabe, D.; Oku, N.; Karim, M. R. U.; Komaki, H.; Igarashi, Y. “A cyclopeptide and three oligomycin-class polyketides produced by an underexplored actinomycete of the genus Pseudosporangium” Beilstein J. Org Chem. 2020, 16, 1100-1110. DOI:10.3762/bjoc.16.97
  8. Nag, A.; Ali, M. A.; Kawaguchi, H.; Saito, S.; Kawasaki, Y.; Miyazaki, S.; Kawamoto, H.; Adi, D. T. N.; Yoshihara, K.; Masuo, S.; Katsuyama, Y.; Kondo, A.; Ogino, C.; Takaya, N.; Kaneko, T.; Ohnishi, Y. “Ultrahigh Thermoresistant Lightweight Bioplastics Developed from Fermentation Products of Cellulosic Feedstock” Adv. Sustainable. Syst. 2020, 2000193. DOI:10.1002/adsu.202000193

2019年以前の論文

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